The prevalence of signs and symptoms of TMD in the general population varies according to the different studies examined. Guidelines of the American Academy of Orofacial Pain estimate that 40% to 75% of the population displays at least one sign of the disease and 33% of the population reports at least 1 symptom. However, only 5% to 10% of adults with TMD symptoms require treatment and even fewer develop chronic or debilitating symptoms. The disorder is 1.5 to 2 times more prevalent in women than in men. Pain tends to occur after puberty, with the highest prevalence occurring in women aged 20 to 40 years.